Ex (nm)
|
492
|
Em (nm)
|
515
|
分子量
|
1147.96
|
溶劑
|
DMSO
|
存儲(chǔ)條件
|
在零下15度以下保存, 避免光照
|
鈣離子熒光探針Cal-520N, AM是美國AAT Bioquest生產(chǎn)的用于標(biāo)記鈣離子的熒光探針,Cal-520®提供強(qiáng)大的均勻熒光測定工具,用于檢測細(xì)胞內(nèi)鈣動(dòng)員。Cal-520®AM是一種新型熒光鈣敏感染料,與現(xiàn)有的綠色鈣指示劑(如Fluo-3 AM和Fluo-4 AM)相比,具有顯著信噪比和細(xì)胞內(nèi)保留。表達(dá)通過鈣信號(hào)傳導(dǎo)的GPCR或鈣通道的細(xì)胞可以預(yù)裝載可以穿過細(xì)胞膜的Cal-520 AM。一旦進(jìn)入細(xì)胞內(nèi),Cal-520 AM的親脂性阻斷基團(tuán)被酯酶裂解,產(chǎn)生帶負(fù)電荷的熒光染料,留在細(xì)胞內(nèi)。與鈣結(jié)合后,其熒光大大增強(qiáng)。當(dāng)用激動(dòng)劑刺激細(xì)胞時(shí),該受體表示細(xì)胞內(nèi)鈣的釋放,這顯著增加了Cal-520®的熒光。Cal-520®AM具有長波長,高靈敏度和> 100倍熒光增強(qiáng)的特性,是測量細(xì)胞鈣的理想指示劑。高信噪比和更好的細(xì)胞內(nèi)保留使Cal-520®鈣測定成為評(píng)估GPCR和鈣通道靶標(biāo)以及篩選其激動(dòng)劑和拮抗劑的有力工具。百螢生物是AAT Bioquest 的中國代理商,為您提供的鈣離子熒光探針
參考文獻(xiàn)
A Critical Period for the Rapid Modification of Synaptic Properties at the VPm Relay Synapse
Authors: Libiao Pan, Junhua Yang, Qian Yang, Xiaomeng Wang, Liya Zhu, Yali Liu, Huifang Lou, Chou Xu, Ying Shen, Hao Wang
Journal: Frontiers in molecular neuroscience (2017)
Advances in Two-Photon Scanning and Scanless Microscopy Technologies for Functional Neural Circuit Imaging
Authors: Simon R Schultz, Caroline S Copeland, Amanda J Foust, Peter Quicke, Renaud Schuck
Journal: Proceedings of the IEEE (2017): 139--157
Bidirectional communication between sensory neurons and osteoblasts in an in vitro co-culture system
Authors: Daisuke Kodama, Takao Hirai, Hisataka Kondo, Kazunori Hamamura, Akifumi Togari
Journal: FEBS Letters (2017)
Ca 2+ signals initiate at immobile IP 3 receptors adjacent to ER-plasma membrane junctions
Authors: Nagendra Babu Thillaiappan, Alap P Chavda, Stephen C Tovey, David L Prole, Colin W Taylor
Journal: Nature Communications (2017): 1505
Calcium Imaging Across Large Areas of Intact Vascular Endothelium Reveals Stimulus-Specific Sensory Cells
Authors: Matthew D Lee, Calum Wilson, John G McCarron
Journal: The FASEB Journal (2017): 1005--8
。